Rabbit Secondary Antibodies
Cayman Chemical p120CATnInCTerm RabbIt 100uL
An MTH1 inhibitor (IC50 72 nM) selective for MTH1 over a panel of 456 kinases at 1 UM induces oxidative DNA damage and apoptosis in SGC-7901 and BGC-823 cancer cells at 30 UM induces ROS production and apoptosis in the same model inhibits proliferation in a panel of 14 cancer cell lines expressing wild-type or various mutant forms of K-Ras or p53 (IC50s 0.52-7.4 UM) inhibits tumor growth in an SW 480 mouse xenograft model at 25 mg/kg
Cayman Chemical STAT3aN-Term RabbIt Mon 100uL
An internal standard for the quantification of nicotinamide riboside by GC- or LC-MS
Cayman Chemical SynaptophysInCTRm RabbIt 100uL
A DGK inhibitor (Ki 58 M) reduces basal and thrombin-stimulated phosphatidic acid levels in washed isolated human platelets at 30 100 and 500 M
Cayman Chemical OX40CD134CTerm RabbIt Mo 100uL
A catechol estrogen and minor metabolite of estrogen production is increased in microsomes prepared from human mammary adenocarcinoma and fibroadenoma microsomes compared with microsomes prepared from non-cancerous tissues induces renal tumor formation in male hamsters at 25 mg/animal
ABclonal Technology RNF8 Rabbit mAb
The protein encoded by this gene contains a RING finger motif and an FHA domain This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2) including UBE2E1 UBCH6 UBE2E2 and UBE2E3 and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest Alternative splicing results in multiple transcript variants
ABclonal Technology CBX1/HP1 beta Rabbit mAb
This gene encodes a highly conserved nonhistone protein which is a member of the heterochromatin protein family The protein is enriched in the heterochromatin and associated with centromeres The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins The protein may play an important role in the epigenetic control of chromatin structure and gene expression Several related pseudogenes are located on chromosomes 1 3 and X Multiple alternatively spliced variants encoding the same protein have been identified
ABclonal Technology MFI2 Rabbit mAb
The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily The importance of the iron binding function has not yet been identified This gene resides in the same region of chromosome 3 as members of the transferrin superfamily Alternative splicing results in two transcript variants
United States Biological Corporation ANTI-C1QTNF1 NT RABBIT POLY AN
NC3728128 ANTI-C1QTNF1 NT RABBIT POLY AN
ABclonal Technology NDUFV1 Rabbit mAb
The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V) This gene encodes a 51 kDa subunit of the NADH ubiquinone oxidoreductase complex I a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites Defects in complex I are a common cause of mitochondrial dysfunction a syndrome that occurs in approximately 1 in 10 000 live births Mitochondrial complex I deficiency is linked to myopathies encephalomyopathies and neurodegenerative disorders such as Parkinson s disease and Leigh syndrome Alternative splicing results in multiple transcript variants encoding distinct isoforms
ABclonal Technology TPH-1 Rabbit mAb
This gene encodes a member of the aromatic amino acid hydroxylase family The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin an important hormone and neurotransmitter Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders including schizophrenia somatic anxiety anger-related traits bipolar disorder suicidal behavior addictions and others
Jackson Immuno Research Labs Alexa Fluor 488-AffiniPure F(ab')2 Fragment Rabbit Anti-Mouse IgG (H+L)
Alexa Fluor 488-AffiniPure F(ab')2 Fragment Rabbit Anti-Mouse IgG (H+L)
ABclonal Technology DC-SIGNR/CD299 Rabbit mAb
This gene encodes a C-type lectin involved in cell adhesion and pathogen recognition It recognizes a variety of pathogens including tuberculosis mycobacteria and viruses like Ebola HIV-1 influenza A West Nile virus and SARS-CoV The protein has four domains a C-terminal carbohydrate recognition domain a flexible neck domain a transmembrane region and an N-terminal cytoplasmic domain for internalization It is closely related to CD209 (DC-SIGN) with differences in viral recognition and expression This gene is highly expressed in liver endothelial cells lymph nodes and placenta Polymorphisms in the neck domain are linked to resistance to SARS infection